6BQ0
Structure of human monoacylglycerol lipase bound to a covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Monoglyceride lipase | polymer | 348 | 38258.7 | 2 | UniProt (Q99685) Pfam (PF12146) In PDB | Homo sapiens (Human) | MGL,HU-K5,Lysophospholipase homolog,Lysophospholipase-like,Monoacylglycerol lipase,MAGL |
| 2 | A, B | 1-({(1R,5S,6r)-6-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carbonyl}oxy)pyrrolidine-2,5-dione | non-polymer | 384.4 | 2 | Chemie (E3A) | |||
| 3 | water | water | 18.0 | 443 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 303 (UniProt: Q99685)
| PDB | External Database | Details |
|---|---|---|
| Met -23 | - | expression tag |
| Ala -22 | - | expression tag |
| Ser -21 | - | expression tag |
| Arg -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Ala -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Arg -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 304 | - | expression tag |
| Glu 305 | - | expression tag |
| Val 306 | - | expression tag |
| Asp 307 | - | expression tag |
| Leu 308 | - | expression tag |
| Gln 309 | - | expression tag |
| Gly 310 | - | expression tag |
| Asp 311 | - | expression tag |
| His 312 | - | expression tag |
| Gly 313 | - | expression tag |
| Leu 314 | - | expression tag |
| Ser 315 | - | expression tag |
| Ala 316 | - | expression tag |
| Trp 317 | - | expression tag |
| Ser 318 | - | expression tag |
| His 319 | - | expression tag |
| Pro 320 | - | expression tag |
| Gln 321 | - | expression tag |
| Phe 322 | - | expression tag |
| Glu 323 | - | expression tag |
| Lys 324 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76517.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 768.7 | |
| All* | Total formula weight | 77286.1 |
