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6BQ0

Structure of human monoacylglycerol lipase bound to a covalent inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004622molecular_functionlysophospholipase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0006639biological_processacylglycerol metabolic process
A0006954biological_processinflammatory response
A0009966biological_processregulation of signal transduction
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0019369biological_processarachidonic acid metabolic process
A0019433biological_processtriglyceride catabolic process
A0042803molecular_functionprotein homodimerization activity
A0046464biological_processacylglycerol catabolic process
A0047372molecular_functionacylglycerol lipase activity
A0050727biological_processregulation of inflammatory response
A0051930biological_processregulation of sensory perception of pain
A0052651biological_processmonoacylglycerol catabolic process
A0052689molecular_functioncarboxylic ester hydrolase activity
A2000124biological_processregulation of endocannabinoid signaling pathway
B0004622molecular_functionlysophospholipase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0006639biological_processacylglycerol metabolic process
B0006954biological_processinflammatory response
B0009966biological_processregulation of signal transduction
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0019369biological_processarachidonic acid metabolic process
B0019433biological_processtriglyceride catabolic process
B0042803molecular_functionprotein homodimerization activity
B0046464biological_processacylglycerol catabolic process
B0047372molecular_functionacylglycerol lipase activity
B0050727biological_processregulation of inflammatory response
B0051930biological_processregulation of sensory perception of pain
B0052651biological_processmonoacylglycerol catabolic process
B0052689molecular_functioncarboxylic ester hydrolase activity
B2000124biological_processregulation of endocannabinoid signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue E3A A 401
ChainResidue
AALA51
ASER122
AMET123
ALEU176
AGLY177
ALEU241
ACYS242
AHOH547

site_idAC2
Number of Residues18
Detailsbinding site for Di-peptide E3A B 401 and SER B 122
ChainResidue
BHIS121
BMET123
BGLY124
BGLY125
BALA126
BILE145
BSER146
BPRO147
BLEU148
BLEU176
BGLY177
BILE179
BLEU213
BLEU214
BLEU241
BCYS242
BHIS269
BALA51

site_idAC3
Number of Residues18
Detailsbinding site for Di-peptide E3A B 401 and SER B 122
ChainResidue
BALA51
BHIS121
BMET123
BGLY124
BGLY125
BALA126
BILE145
BSER146
BPRO147
BLEU148
BLEU176
BGLY177
BILE179
BLEU213
BLEU214
BLEU241
BCYS242
BHIS269

Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. VFLLGHSMGG
ChainResidueDetails
AVAL116-GLY125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:19957260
ChainResidueDetails
ASER122
BSER122

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Charge relay system => ECO:0000305|PubMed:19957260
ChainResidueDetails
AASP239
AHIS269
BASP239
BHIS269

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O35678
ChainResidueDetails
ATHR10
BTHR10

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:O35678
ChainResidueDetails
ATYR58
BTYR58

219869

PDB entries from 2024-05-15

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