5ZHP
M3 muscarinic acetylcholine receptor in complex with a selective antagonist
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Muscarinic acetylcholine receptor M3,Endolysin,Endolysin,Muscarinic acetylcholine receptor M3 | polymer | 418 | 47928.1 | 2 | UniProt (P08483) UniProt (D9IEF7) Pfam (PF00001) Pfam (PF00959) UniProt (by SIFTS) (P00720) In PDB | Rattus norvegicus (Rat) | Lysis protein,Lysozyme,Muramidase,Lysis protein,Lysozyme,Muramidase |
2 | C | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
3 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
4 | A, B | (1R,2R,4S,5S,7s)-7-({[4-fluoro-2-(thiophen-2-yl)phenyl]carbamoyl}oxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-9-ium | non-polymer | 389.5 | 2 | Chemie (9EC) | |||
5 | B | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
6 | B | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) |
Sequence modifications
A, B: 57 - 259 (UniProt: P08483)
A, B: 1001 - 1012 (UniProt: D9IEF7)
A, B: 1018 - 1118 (UniProt: D9IEF7)
A, B: 482 - 569 (UniProt: P08483)
PDB | External Database | Details |
---|---|---|
Gly 56 | - | expression tag |
Arg 154 | Ser 154 | engineered mutation |
A, B: 1018 - 1118 (UniProt: D9IEF7)
PDB | External Database | Details |
---|---|---|
Gly 1013 | - | linker |
Gly 1014 | - | linker |
Ser 1015 | - | linker |
Gly 1016 | - | linker |
Gly 1017 | - | linker |
Ala 1054 | Cys 97 | engineered mutation |
PDB | External Database | Details |
---|---|---|
His 570 | - | expression tag |
His 571 | - | expression tag |
His 572 | - | expression tag |
His 573 | - | expression tag |
His 574 | - | expression tag |
His 575 | - | expression tag |
His 576 | - | expression tag |
His 577 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 95856.3 | |
Branched | Number of molecules | 1 |
Total formula weight | 342.3 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1447.6 | |
All* | Total formula weight | 97646.2 |