5UNG
XFEL structure of human angiotensin II type 2 receptor (Orthorhombic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Chimera protein of Type-2 angiotensin II receptor and Soluble cytochrome b562 | polymer | 411 | 46506.5 | 1 | UniProt (P0ABE7) UniProt (P50052) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,Angiotensin II type-2 receptor,AT2 |
| 2 | B | N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide | non-polymer | 623.7 | 1 | Chemie (8ES) | |||
| 3 | B | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 1 | Chemie (OLC) | |||
| 4 | B | OLEIC ACID | non-polymer | 282.5 | 1 | Chemie (OLA) | |||
| 5 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
B: 1001 - 1106 (UniProt: P0ABE7)
B: 35 - 335 (UniProt: P50052)
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
| Gly 1107 | - | linker |
| Ser 1108 | - | linker |
| Gly 1109 | - | linker |
| Ser 1110 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 46506.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1262.7 | |
| All* | Total formula weight | 47769.3 |
