5UNG
XFEL structure of human angiotensin II type 2 receptor (Orthorhombic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004945 | molecular_function | angiotensin type II receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0006954 | biological_process | inflammatory response |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0042981 | biological_process | regulation of apoptotic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0097746 | biological_process | blood vessel diameter maintenance |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 8ES B 1201 |
| Chain | Residue |
| B | TYR51 |
| B | LYS215 |
| B | TRP269 |
| B | PHE272 |
| B | ILE304 |
| B | PHE308 |
| B | TRP100 |
| B | TYR103 |
| B | LEU124 |
| B | THR125 |
| B | MET128 |
| B | PHE129 |
| B | THR178 |
| B | ARG182 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue OLC B 1202 |
| Chain | Residue |
| B | PRO48 |
| B | TYR52 |
| B | THR102 |
| B | SER105 |
| B | ALA228 |
| B | THR229 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIfFITCMSVDRYQsV |
| Chain | Residue | Details |
| B | ALA130-VAL146 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| B | TRP1007 | |
| B | ILE1102 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A |
| Chain | Residue | Details |
| B | ALA46-CYS70 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 51 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A |
| Chain | Residue | Details |
| B | CYS71-SER80 | |
| B | ASP141-GLN159 | |
| B | GLY233-MET257 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A |
| Chain | Residue | Details |
| B | ILE81-TYR104 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 45 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A |
| Chain | Residue | Details |
| B | SER105-PRO114 | |
| B | ARG182-GLN206 | |
| B | ALA282-ALA294 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A |
| Chain | Residue | Details |
| B | VAL115-VAL140 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A |
| Chain | Residue | Details |
| B | ALA160-PHE181 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A |
| Chain | Residue | Details |
| B | TRP207-PHE232 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A |
| Chain | Residue | Details |
| B | ALA258-LEU281 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A |
| Chain | Residue | Details |
| B | VAL295-PHE320 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:31899086, ECO:0007744|PDB:6JOD |
| Chain | Residue | Details |
| B | TYR103 | |
| B | TYR104 | |
| B | ARG182 | |
| B | TYR204 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29967536, ECO:0000305|PubMed:31899086, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD |
| Chain | Residue | Details |
| B | LYS215 | |
| B | ASP279 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29967536, ECO:0007744|PDB:5XJM |
| Chain | Residue | Details |
| B | ASP297 |
