5JPN

Structure of human complement C4 rebuilt using iMDFF

Replaces:  4FXK

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Complement C4-A	polymer	656	71761.7	1	UniProt (P0C0L4) Pfam (PF21145) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) In PDB	Homo sapiens (Human)	Acidic complement C4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
2	B	Complement C4-A	polymer	767	84270.1	1	UniProt (P0C0L4) Pfam (PF01821) Pfam (PF00207) Pfam (PF07678) In PDB	Homo sapiens (Human)	Acidic complement C4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
3	C	Complement C4-A	polymer	290	32986.5	1	UniProt (P0C0L4) Pfam (PF01759) Pfam (PF07677) In PDB	Homo sapiens (Human)	Acidic complement C4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
4	D	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
5	E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	F, G	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G22768VO)
7	A, B, C	TRIMETHYL LEAD ION	non-polymer		252.3	4	Chemie (PBM)
8	B	2-acetamido-2-deoxy-alpha-D-galactopyranose	non-polymer		221.2	1	Chemie (A2G)

Sequence modifications

B: 680 - 1446 (UniProt: P0C0L4)

PDB	External Database	Details
Ser 1201	Thr 1201	variant

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	189018.3
Branched	Number of molecules	4
	Total formula weight	2832.6
Non-Polymers*	Number of molecules	5
	Total formula weight	1230.4
All*	Total formula weight	193081.3

*Water molecules are not included.