5HO6
CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH CMPD.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hepatocyte growth factor receptor | polymer | 312 | 35306.9 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | A | 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea | non-polymer | 550.6 | 1 | Chemie (63K) | |||
| 3 | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A: 1049 - 1360 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Phe 1194 | Tyr 1194 | engineered mutation |
| Phe 1234 | Tyr 1234 | engineered mutation |
| Asp 1235 | Tyr 1235 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35306.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 550.6 | |
| All* | Total formula weight | 35857.5 |
