5HMK
HDM2 in complex with a 3,3-Disubstituted Piperidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | E3 ubiquitin-protein ligase Mdm2 | polymer | 109 | 12526.3 | 2 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
| 2 | A, B | {4-[2-(2-hydroxyethoxy)phenyl]piperazin-1-yl}[(2R,3S)-2-propyl-3-[4-(trifluoromethyl)phenoxy]-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-3-yl]methanone | non-polymer | 708.7 | 2 | Chemie (62Q) | |||
| 3 | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 125 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Tyr 55 | Phe 61 | engineered mutation |
| His 76 | Tyr 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25052.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1417.4 | |
| All* | Total formula weight | 26470.0 |
