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5HMK

HDM2 in complex with a 3,3-Disubstituted Piperidine

Summary for 5HMK
Entry DOI10.2210/pdb5hmk/pdb
Related5HMH 5HMI
DescriptorE3 ubiquitin-protein ligase Mdm2, {4-[2-(2-hydroxyethoxy)phenyl]piperazin-1-yl}[(2R,3S)-2-propyl-3-[4-(trifluoromethyl)phenoxy]-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-3-yl]methanone (3 entities in total)
Functional Keywordsoncology, e3 ubiquitin-protein ligase, p53/tp53, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains2
Total formula weight26470.03
Authors
Scapin, G. (deposition date: 2016-01-16, release date: 2016-04-06, Last modification date: 2024-03-06)
Primary citationBogen, S.L.,Pan, W.,Gibeau, C.R.,Lahue, B.R.,Ma, Y.,Nair, L.G.,Seigel, E.,Shipps, G.W.,Tian, Y.,Wang, Y.,Lin, Y.,Liu, M.,Liu, S.,Mirza, A.,Wang, X.,Lipari, P.,Seidel-Dugan, C.,Hicklin, D.J.,Bishop, W.R.,Rindgen, D.,Nomeir, A.,Prosise, W.,Reichert, P.,Scapin, G.,Strickland, C.,Doll, R.J.
Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
Acs Med.Chem.Lett., 7:324-329, 2016
Cited by
PubMed: 26985323
DOI: 10.1021/acsmedchemlett.5b00472
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.17 Å)
Structure validation

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