5H2U

Crystal structure of PTK6 Kinase Domain complexed with Dasatinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Protein-tyrosine kinase 6	polymer	267	30864.6	4	UniProt (Q13882) Pfam (PF07714) In PDB	Homo sapiens (Human)	Breast tumor kinase,Tyrosine-protein kinase BRK
2	A, B, C, D	N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE	non-polymer		488.0	4	Chemie (1N1)
3	A, B, C, D	GLYCEROL	non-polymer		92.1	12	Chemie (GOL)
4		water	water		18.0	501	Chemie (HOH)

Sequence modifications

A, B, C, D: 185 - 446 (UniProt: Q13882)

PDB	External Database	Details
Cxm 184	-	expression tag
Thr 433	Cys 433	engineered mutation
His 447	-	expression tag
His 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	123458.5
Non-Polymers*	Number of molecules	16
	Total formula weight	3057.2
All*	Total formula weight	126515.6

*Water molecules are not included.