5H2U

Crystal structure of PTK6 Kinase Domain complexed with Dasatinib

Summary for 5H2U

Entry DOI	10.2210/pdb5h2u/pdb
Descriptor	Protein-tyrosine kinase 6, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, GLYCEROL, ... (4 entities in total)
Functional Keywords	transferase, kinase, brk, ptk6, dasatinib
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q13882
Total number of polymer chains	4
Total formula weight	126515.64
Authors	Thakur, M.K.,Birudukota, S.,Swaminathan, S.,Tyagi, R.,Gosu, R. (deposition date: 2016-10-18, release date: 2017-01-04, Last modification date: 2023-11-08)
Primary citation	Thakur, M.K.,Birudukota, S.,Swaminathan, S.,Battula, S.K.,Vadivelu, S.,Tyagi, R.,Gosu, R. Co-crystal structures of PTK6: With Dasatinib at 2.24 angstrom , with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 angstrom resolution Biochem. Biophys. Res. Commun., 482:1289-1295, 2017 Cited by PubMed: 27993680 DOI: 10.1016/j.bbrc.2016.12.030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation