5H2U
Crystal structure of PTK6 Kinase Domain complexed with Dasatinib
Summary for 5H2U
Entry DOI | 10.2210/pdb5h2u/pdb |
Descriptor | Protein-tyrosine kinase 6, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | transferase, kinase, brk, ptk6, dasatinib |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q13882 |
Total number of polymer chains | 4 |
Total formula weight | 126515.64 |
Authors | Thakur, M.K.,Birudukota, S.,Swaminathan, S.,Tyagi, R.,Gosu, R. (deposition date: 2016-10-18, release date: 2017-01-04, Last modification date: 2023-11-08) |
Primary citation | Thakur, M.K.,Birudukota, S.,Swaminathan, S.,Battula, S.K.,Vadivelu, S.,Tyagi, R.,Gosu, R. Co-crystal structures of PTK6: With Dasatinib at 2.24 angstrom , with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 angstrom resolution Biochem. Biophys. Res. Commun., 482:1289-1295, 2017 Cited by PubMed: 27993680DOI: 10.1016/j.bbrc.2016.12.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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