5GRI

Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+) and citrate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	polymer	339	36682.2	1	UniProt (P50213) Pfam (PF00180) In PDB	Homo sapiens (Human)	Isocitric dehydrogenase subunit alpha,NAD(+)-specific ICDH subunit alpha
2	B	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	polymer	354	38867.5	1	UniProt (P51553) Pfam (PF00180) In PDB	Homo sapiens (Human)	Isocitric dehydrogenase subunit gamma,NAD(+)-specific ICDH subunit gamma
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	B	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
5		water	water		18.0	111	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75549.7
Non-Polymers*	Number of molecules	3
	Total formula weight	240.7
All*	Total formula weight	75790.4

*Water molecules are not included.