5GRI

Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+) and citrate

Summary for 5GRI

• Entry DOI: 10.2210/pdb5gri/pdb
• Related: 5GRE 5GRF 5GRH 5GRL
• Descriptor: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: allosteric regulation, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Cellular location: Mitochondrion: P50213 P51553
• Total number of polymer chains: 2
• Total formula weight: 75790.43

Authors

Ma, T.,Peng, Y.,Ding, J. (deposition date: 2016-08-11, release date: 2017-02-15, Last modification date: 2023-11-08)

• Primary citation: Ma, T.,Peng, Y.,Huang, W.,Ding, J.; Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.; Sci Rep, 7:40921-40921, 2017; PubMed: 28098230; DOI: 10.1038/srep40921

Experimental method

X-RAY DIFFRACTION (2.31 Å)