5FA5
Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein arginine N-methyltransferase 5 | polymer | 650 | 74281.3 | 1 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) In PDB | Homo sapiens (Human) | 72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs |
| 2 | B | Methylosome protein 50 | polymer | 367 | 39857.5 | 1 | UniProt (Q9BQA1) Pfam (PF00400) In PDB | Homo sapiens (Human) | MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50 |
| 3 | C | Histone H4 | polymer | 20 | 2001.4 | 1 | UniProt (P62805) In PDB | Homo sapiens | |
| 4 | A | 5'-DEOXY-5'-METHYLTHIOADENOSINE | non-polymer | 297.3 | 1 | Chemie (MTA) | |||
| 5 | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence modifications
A: 1 - 637 (UniProt: O14744)
B: 2 - 342 (UniProt: Q9BQA1)
| PDB | External Database | Details |
|---|---|---|
| Met -12 | - | initiating methionine |
| Asp -11 | - | expression tag |
| Tyr -10 | - | expression tag |
| Lys -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Thr 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -24 | - | initiating methionine |
| Ser -23 | - | expression tag |
| Tyr -22 | - | expression tag |
| Tyr -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Tyr -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Pro -10 | - | expression tag |
| Thr -9 | - | expression tag |
| Thr -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Asn -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Tyr -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 116140.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 297.3 | |
| All* | Total formula weight | 116437.4 |
