5DZD

Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide

Replaces:  4ROI

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	E3 ubiquitin-protein ligase Itchy homolog	polymer	47	5503.2	2	UniProt (Q96J02) Pfam (PF00397) In PDB	Homo sapiens (Human)	Itch, Atrophin-1-interacting protein 4, AIP4, NFE2-associated polypeptide 1, NAPP1
2	C, D	Thioredoxin-interacting protein	polymer	14	1359.6	2	UniProt (Q9H3M7) In PDB	Homo sapiens	txnip, Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1
3	A, B, C, D	UNKNOWN ATOM OR ION	non-polymer			17	Chemie (UNX)
4		water	water		18.0	60	Chemie (HOH)

Sequence modifications

A, B: 475 - 514 (UniProt: Q96J02)

PDB	External Database	Details
Gly 468	-	expression tag
Arg 469	-	expression tag
Arg 470	-	expression tag
Ala 471	-	expression tag
Ser 472	-	expression tag
Val 473	-	expression tag
Glu 474	-	expression tag

C, D: 327 - 338 (UniProt: Q9H3M7)

PDB	External Database	Details
Ace 326	-	acetylation
Nh2 339	-	amidation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	13725.5
Non-Polymers*	Number of molecules	17
	Total formula weight	0.0
All*	Total formula weight	13725.5

*Water molecules are not included.