5C2A
PDE10 complexed with 6-chloro-2-cyclopropyl-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-pyrimidin-4-amine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 362 | 41495.5 | 2 | UniProt (Q9Y233) In PDB | Homo sapiens (Human) | |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A, B | 6-chloro-2-cyclopropyl-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methylpyrimidin-4-amine | non-polymer | 308.8 | 2 | Chemie (4Y2) | |||
5 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A, B: 439 - 779 (UniProt: Q9Y233)
PDB | External Database | Details |
---|---|---|
Met 418 | - | initiating methionine |
Gly 419 | - | expression tag |
Ser 420 | - | expression tag |
Ser 421 | - | expression tag |
His 422 | - | expression tag |
His 423 | - | expression tag |
His 424 | - | expression tag |
His 425 | - | expression tag |
His 426 | - | expression tag |
His 427 | - | expression tag |
Ser 428 | - | expression tag |
Ser 429 | - | expression tag |
Gly 430 | - | expression tag |
Leu 431 | - | expression tag |
Val 432 | - | expression tag |
Pro 433 | - | expression tag |
Arg 434 | - | expression tag |
Gly 435 | - | expression tag |
Ser 436 | - | expression tag |
His 437 | - | expression tag |
Met 438 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 82991.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 797.1 | |
All* | Total formula weight | 83788.1 |