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5C2A

PDE10 complexed with 6-chloro-2-cyclopropyl-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-pyrimidin-4-amine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue ZN A 801
ChainResidue
AHIS519
AHIS553
AASP554
AASP664
AHOH912
AHOH919

site_idAC2
Number of Residues6
Detailsbinding site for residue MG A 802
ChainResidue
AHOH912
AHOH941
AHOH959
AASP554
AHOH904
AHOH907

site_idAC3
Number of Residues11
Detailsbinding site for residue 4Y2 A 803
ChainResidue
ATYR514
AHIS515
ASER667
AVAL668
ATYR683
APHE686
AGLN716
APHE719
AHOH902
AHOH903
AHOH952

site_idAC4
Number of Residues6
Detailsbinding site for residue ZN B 801
ChainResidue
BHIS519
BHIS553
BASP554
BASP664
BHOH923
BHOH942

site_idAC5
Number of Residues6
Detailsbinding site for residue MG B 802
ChainResidue
BASP554
BHOH906
BHOH911
BHOH923
BHOH932
BHOH939

site_idAC6
Number of Residues10
Detailsbinding site for residue 4Y2 B 803
ChainResidue
BHIS515
BLEU665
BVAL668
BILE682
BTYR683
BPHE686
BGLN716
BPHE719
BHOH908
BHOH933

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
ChainResidueDetails
AHIS553-TYR564

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
ChainResidueDetails
AGLY630
AGLN649
BCYS552
BGLU596
BGLY630
BGLN649
ACYS552
AGLU596

221051

PDB entries from 2024-06-12

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