5AYF
Crystal structure of SET7/9 in complex with cyproheptadine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Histone-lysine N-methyltransferase SETD7 | polymer | 263 | 28864.2 | 1 | UniProt (Q8WTS6) Pfam (PF02493) Pfam (PF00856) In PDB | Homo sapiens (Human) | Histone H3-K4 methyltransferase SETD7,H3-K4-HMTase SETD7,Lysine N-methyltransferase 7,SET domain-containing protein 7,SET7/9 |
| 2 | A | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 3 | A | 4-(dibenzo[1,2-a:2',1'-d][7]annulen-11-ylidene)-1-methyl-piperidine | non-polymer | 287.4 | 1 | Chemie (C7H) | |||
| 4 | A | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 5 | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A: 111 - 366 (UniProt: Q8WTS6)
| PDB | External Database | Details |
|---|---|---|
| Gly 104 | - | expression tag |
| Ser 105 | - | expression tag |
| Ser 106 | - | expression tag |
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
| Ser 109 | - | expression tag |
| Gly 110 | - | expression tag |
| Unk 337 | Tyr 337 | see sequence details |
| Unk 338 | Asp 338 | see sequence details |
| Unk 339 | His 339 | see sequence details |
| Unk 340 | Ser 340 | see sequence details |
| Unk 341 | Pro 341 | see sequence details |
| Unk 342 | Pro 342 | see sequence details |
| Unk 343 | Gly 343 | see sequence details |
| Unk 344 | Lys 344 | see sequence details |
| Unk 345 | Ser 345 | see sequence details |
| Unk 346 | Gly 346 | see sequence details |
| Unk 347 | Pro 347 | see sequence details |
| Unk 348 | Glu 348 | see sequence details |
| Unk 349 | Ala 349 | see sequence details |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28864.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 808.0 | |
| All* | Total formula weight | 29672.2 |
