5AYF

Crystal structure of SET7/9 in complex with cyproheptadine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005694	cellular_component	chromosome
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0140945	molecular_function	histone H3K4 monomethyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue SAM A 401

Chain	Residue
A	ILE223
A	HIS297
A	TYR335
A	TRP352
A	HOH534
A	HOH579
A	HOH581
A	HOH588
A	HOH626
A	ALA226
A	GLU228
A	GLY264
A	ASN265
A	HIS293
A	LYS294
A	ALA295
A	ASN296

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site_id	AC2
Number of Residues	6
Details	binding site for residue C7H A 402

Chain	Residue
A	TYR245
A	ASN263
A	GLY264
A	THR266
A	TYR305
A	TYR335

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site_id	AC3
Number of Residues	10
Details	binding site for residue TRS A 403

Chain	Residue
A	GLY237
A	PRO238
A	THR240
A	ALA362
A	THR363
A	GLN365
A	HOH523
A	HOH533
A	HOH604
A	HOH609

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855

Chain	Residue	Details
A	ALA226
A	ASN296
A	HIS297

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855

Chain	Residue	Details
A	GLU356

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site_id	SWS_FT_FI3
Number of Residues	5
Details	SITE: Histone H3K4 binding => ECO:0000269|PubMed:12540855

Chain	Residue	Details
A	TYR245
A	ASP256
A	THR266
A	LYS317
A	TYR335

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 350

Chain	Residue	Details
A	TYR245	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	HIS293	electrostatic stabiliser, hydrogen bond acceptor
A	HIS297	electrostatic stabiliser, hydrogen bond acceptor
A	TYR305	activator, electrostatic stabiliser, hydrogen bond acceptor
A	TYR335	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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