5A6I
V122I Transthyretin structure in complex with Tolcalpone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | TRANSTHYRETIN | polymer | 128 | 13922.6 | 1 | UniProt (P02766) Pfam (PF00576) In PDB | HOMO SAPIENS (HUMAN) | ATTR, PREALBUMIN, TBPA |
| 2 | A | Tolcapone | non-polymer | 273.2 | 1 | Chemie (TCW) | |||
| 3 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 1 - 127 (UniProt: P02766)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Ile 122 | Val 142 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13922.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 273.2 | |
| All* | Total formula weight | 14195.8 |
