5A6I
V122I Transthyretin structure in complex with Tolcalpone
Summary for 5A6I
Entry DOI | 10.2210/pdb5a6i/pdb |
Descriptor | TRANSTHYRETIN, Tolcapone (3 entities in total) |
Functional Keywords | transport protein, transprot protein, transthyretin, amyloid |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 1 |
Total formula weight | 14195.82 |
Authors | Reverter, D.,Gallego, P.,Santana, R.,Ventura, S. (deposition date: 2015-06-26, release date: 2016-02-24, Last modification date: 2017-08-23) |
Primary citation | Reverter, D.,Gallego, P.,Santana, R.,Ventura, S. Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity Nat.Commun., 7:10787-, 2016 Cited by PubMed: 26902880DOI: 10.1038/NCOMMS10787 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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