5A6I

V122I Transthyretin structure in complex with Tolcalpone

Summary for 5A6I

Entry DOI	10.2210/pdb5a6i/pdb
Descriptor	TRANSTHYRETIN, Tolcapone (3 entities in total)
Functional Keywords	transport protein, transprot protein, transthyretin, amyloid
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Secreted: P02766
Total number of polymer chains	1
Total formula weight	14195.82
Authors	Reverter, D.,Gallego, P.,Santana, R.,Ventura, S. (deposition date: 2015-06-26, release date: 2016-02-24, Last modification date: 2017-08-23)
Primary citation	Reverter, D.,Gallego, P.,Santana, R.,Ventura, S. Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity Nat.Commun., 7:10787-, 2016 Cited by PubMed: 26902880 DOI: 10.1038/NCOMMS10787 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation