4V06

Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	TRYPTOPHAN 5-HYDROXYLASE 2	polymer	349	40251.7	2	UniProt (Q8IWU9) Pfam (PF00351) In PDB	HOMO SAPIENS (HUMAN)	NEURONAL TRYPTOPHAN HYDROXYLASE, TRYPTOPHAN 5-MONOOXYGENASE 2
2	A, B	IMIDAZOLE	non-polymer		69.1	2	Chemie (IMD)
3	A, B	FE (III) ION	non-polymer		55.8	2	Chemie (FE)
4		water	water		18.0	111	Chemie (HOH)

Sequence modifications

A, B: 148 - 490 (UniProt: Q8IWU9)

PDB	External Database	Details
Leu 142	-	expression tag
Tyr 143	-	expression tag
Phe 144	-	expression tag
Gln 145	-	expression tag
Ser 146	-	expression tag
Met 147	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80503.5
Non-Polymers*	Number of molecules	4
	Total formula weight	249.9
All*	Total formula weight	80753.3

*Water molecules are not included.