4UI2
Crystal structure of the ternary RGMB-BMP2-NEO1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | NEOGENIN | polymer | 264 | 29221.8 | 1 | UniProt (P97798) Pfam (PF00041) UniProt (by SIFTS) (Q92859) In PDB | HOMO SAPIENS (HUMAN) | |
| 2 | B | BONE MORPHOGENETIC PROTEIN 2, BMP2 | polymer | 114 | 12923.9 | 1 | UniProt (P12643) Pfam (PF00019) In PDB | HOMO SAPIENS (HUMAN) | |
| 3 | C | REPULSIVE GUIDANCE MOLECULE C, RGMC, HEMOJUVELIN | polymer | 122 | 13318.7 | 1 | UniProt (Q6NW40) Pfam (PF06535) In PDB | HOMO SAPIENS (HUMAN) | |
| 4 | D | REPULSIVE GUIDANCE MOLECULE C, RGMC, HEMOJUVELIN | polymer | 251 | 27945.4 | 1 | UniProt (Q6NW40) Pfam (PF06535) Pfam (PF06534) In PDB | HOMO SAPIENS (HUMAN) | |
| 5 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | B | S,R MESO-TARTARIC ACID | non-polymer | 150.1 | 3 | Chemie (SRT) | |||
| 7 | B | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) |
Sequence modifications
A: 883 - 1133 (UniProt: P97798)
C: 50 - 168 (UniProt: Q6NW40)
D: 169 - 410 (UniProt: Q6NW40)
| PDB | External Database | Details |
|---|---|---|
| Glu 880 | - | expression tag |
| Thr 881 | - | expression tag |
| Gly 882 | - | expression tag |
| Asn 1134 | - | expression tag |
| Gly 1135 | - | expression tag |
| Thr 1136 | - | expression tag |
| Lys 1137 | - | expression tag |
| His 1138 | - | expression tag |
| His 1139 | - | expression tag |
| His 1140 | - | expression tag |
| His 1141 | - | expression tag |
| His 1142 | - | expression tag |
| His 1143 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 47 | - | expression tag |
| Thr 48 | - | expression tag |
| Gly 49 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 411 | - | expression tag |
| Thr 412 | - | expression tag |
| Lys 413 | - | expression tag |
| His 414 | - | expression tag |
| His 415 | - | expression tag |
| His 416 | - | expression tag |
| His 417 | - | expression tag |
| His 418 | - | expression tag |
| His 419 | - | expression tag |
| Gly 225 | Glu 225 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 83409.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 509.3 | |
| All* | Total formula weight | 84505.6 |
