4U7T

Crystal structure of DNMT3A-DNMT3L in complex with histone H3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	DNA (cytosine-5)-methyltransferase 3A	polymer	445	50878.4	2	UniProt (Q9Y6K1) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) In PDB	Homo sapiens (Human)	DNA methyltransferases DNMT3A
2	B, D	DNA (cytosine-5)-methyltransferase 3-like	polymer	209	24119.7	2	UniProt (Q9UJW3) In PDB	Homo sapiens (Human)	DNA methyltransferases DNMT3L
3	F, G	peptide from Histone H3.3	polymer	12	1308.5	2	UniProt (P84243) In PDB	Homo sapiens	histone H3 peptide
4	A, C	ZINC ION	non-polymer		65.4	6	Chemie (ZN)
5	A, C	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
6		water	water		18.0	11	Chemie (HOH)

Sequence modifications

A, C: 476 - 912 (UniProt: Q9Y6K1)

PDB	External Database	Details
Gly 468	-	expression tag
Pro 469	-	expression tag
Leu 470	-	expression tag
Gly 471	-	expression tag
Ser 472	-	expression tag
Pro 473	-	expression tag
Glu 474	-	expression tag
Phe 475	-	expression tag

B, D: 178 - 379 (UniProt: Q9UJW3)

PDB	External Database	Details
Gly 171	-	expression tag
Pro 172	-	expression tag
Leu 173	-	expression tag
Gly 174	-	expression tag
Ser 175	-	expression tag
Glu 176	-	expression tag
Phe 177	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	152613.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1161.3
All*	Total formula weight	153774.4

*Water molecules are not included.