4U7T

Crystal structure of DNMT3A-DNMT3L in complex with histone H3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006306	biological_process	obsolete DNA methylation
A	0008168	molecular_function	methyltransferase activity
A	0010468	biological_process	regulation of gene expression
C	0006306	biological_process	obsolete DNA methylation
C	0008168	molecular_function	methyltransferase activity
C	0010468	biological_process	regulation of gene expression

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	CYS494
A	CYS497
A	CYS514
A	CYS517

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	CYS537
A	CYS540
A	CYS559
A	CYS562

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1003

Chain	Residue
A	CYS554
A	CYS583
A	CYS586
A	CYS549

---

site_id	AC4
Number of Residues	16
Details	binding site for residue SAH A 1004

Chain	Residue
A	PHE640
A	ASP641
A	GLY642
A	ILE643
A	THR645
A	SER663
A	GLU664
A	VAL665
A	CYS666
A	ASP686
A	VAL687
A	ARG688
A	GLY707
A	ARG891
A	SER892
A	TRP893

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN C 1001

Chain	Residue
C	CYS494
C	CYS497
C	CYS514
C	CYS517

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN C 1002

Chain	Residue
C	CYS537
C	CYS540
C	CYS559
C	CYS562

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN C 1003

Chain	Residue
C	CYS549
C	CYS554
C	CYS583
C	CYS586

---

site_id	AC8
Number of Residues	17
Details	binding site for residue SAH C 1004

Chain	Residue
C	PHE640
C	ASP641
C	GLY642
C	ILE643
C	THR645
C	SER663
C	GLU664
C	VAL665
C	CYS666
C	ASP686
C	VAL687
C	ARG688
C	GLY707
C	LEU730
C	ARG891
C	SER892
C	TRP893

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS

Chain	Residue	Details
A	ASP702-SER714

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635

Chain	Residue	Details
F	ARG2
G	ARG2

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088

Chain	Residue	Details
F	THR3
G	THR3

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
F	LYS4
G	LYS4

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594

Chain	Residue	Details
F	GLN5
G	GLN5
A	ASP686
A	ARG891
C	ASP641
C	GLU664
C	ASP686
C	ARG891

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790

Chain	Residue	Details
F	THR6
G	THR6

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P84244

Chain	Residue	Details
F	ARG8
G	ARG8

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708, ECO:0000269|PubMed:7309716

Chain	Residue	Details
F	LYS9
G	LYS9

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15851689, ECO:0000269|PubMed:16185088

Chain	Residue	Details
F	SER10
G	SER10

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:22901803

Chain	Residue	Details
F	THR11
G	THR11

---