4U30

Human mesotrypsin complexed with bikunin Kunitz domain 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Trypsin-3	polymer	224	24257.5	4	UniProt (P35030) Pfam (PF00089) In PDB	Homo sapiens (Human)	Brain trypsinogen,Mesotrypsinogen,Serine protease 3,Serine protease 4,Trypsin III,Trypsin IV
2	X, Y, Z, W	Trypstatin	polymer	59	6454.5	4	UniProt (P02760) Pfam (PF00014) In PDB	Homo sapiens (Human)
3	A, B, C, D	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
4		water	water		18.0	291	Chemie (HOH)

Sequence modifications

A, B, C, D: 16 - 246 (UniProt: P35030)

PDB	External Database	Details
Ala 127	Thr 188	variant
Ala 195	Ser 257	engineered mutation

X, Y, Z, W: 1 - 58 (UniProt: P02760)

PDB	External Database	Details
Ala 5	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	122847.9
Non-Polymers*	Number of molecules	4
	Total formula weight	160.3
All*	Total formula weight	123008.2

*Water molecules are not included.