4TNE

Crystal Structure of Human Transthyretin Thr119Tyr Mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transthyretin	polymer	125	13981.6	2	UniProt (P02766) Pfam (PF00576) In PDB	Homo sapiens (Human)	ATTR,Prealbumin,TBPA
2	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
3		water	water		18.0	101	Chemie (HOH)

Sequence modifications

A, B: 9 - 127 (UniProt: P02766)

PDB	External Database	Details
Tyr 119	Thr 139	engineered mutation
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
His 131	-	expression tag
His 132	-	expression tag
His 133	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	27963.3
Non-Polymers*	Number of molecules	1
	Total formula weight	92.1
All*	Total formula weight	28055.4

*Water molecules are not included.