4Q50
The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with 4-hydroxytamoxifen
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Estrogen receptor | polymer | 260 | 29607.9 | 8 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 2 | A, B, C, D, E... | 4-HYDROXYTAMOXIFEN | non-polymer | 387.5 | 8 | Chemie (OHT) | |||
| 3 | B, H | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 299 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 295 | - | expression tag |
| Asn 296 | - | expression tag |
| Ala 297 | - | expression tag |
| Met 298 | - | expression tag |
| Gly 538 | Asp 538 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 236863.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3292.2 | |
| All* | Total formula weight | 240155.3 |
