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4Q50

The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with 4-hydroxytamoxifen

Summary for 4Q50
Entry DOI10.2210/pdb4q50/pdb
Related4Q13
DescriptorEstrogen receptor, 4-HYDROXYTAMOXIFEN, SULFATE ION, ... (4 entities in total)
Functional Keywordsacquired serm-resistance, breast cancer, activating mutation, serm-er structure, alpha helix, nuclear hormone receptor, hormone binding protein
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains8
Total formula weight240155.33
Authors
Fanning, S.W.,Greene, G.L. (deposition date: 2014-04-15, release date: 2015-04-15, Last modification date: 2024-02-28)
Primary citationFanning, S.W.,Mayne, C.G.,Dharmarajan, V.,Carlson, K.E.,Martin, T.A.,Novick, S.J.,Toy, W.,Green, B.,Panchamukhi, S.,Katzenellenbogen, B.S.,Tajkhorshid, E.,Griffin, P.R.,Shen, Y.,Chandarlapaty, S.,Katzenellenbogen, J.A.,Greene, G.L.
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Elife, 5:-, 2016
Cited by
PubMed: 26836308
DOI: 10.7554/eLife.12792
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.07 Å)
Structure validation

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