4PO7
Structure of the Sortilin:neurotensin complex at excess neurotensin concentration
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sortilin | polymer | 685 | 76774.7 | 1 | UniProt (Q99523) Pfam (PF15902) Pfam (PF15901) In PDB | Homo sapiens (human) | 100 kDa NT receptor, Glycoprotein 95, Gp95, Neurotensin receptor 3, NT3, NTR3 |
2 | N, P | Neurotensin/neuromedin N | polymer | 13 | 1675.9 | 2 | UniProt (P30990) In PDB | Homo sapiens | Large neuromedin N, NmN-125, Neuromedin N, NN, NmN, Neurotensin, NT, Tail peptide |
3 | B, C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
5 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
6 | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A: 45 - 723 (UniProt: Q99523)
PDB | External Database | Details |
---|---|---|
Met 617 | Val 650 | variant |
His 724 | - | expression tag |
His 725 | - | expression tag |
His 726 | - | expression tag |
His 727 | - | expression tag |
His 728 | - | expression tag |
His 729 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 80126.6 | |
Branched | Number of molecules | 2 |
Total formula weight | 1173.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 415.4 | |
All* | Total formula weight | 81715.1 |