4P6W
Crystal Structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glucocorticoid receptor | polymer | 252 | 29284.0 | 1 | UniProt (P04150) Pfam (PF00104) In PDB | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
2 | B | Nuclear receptor coactivator 2 | polymer | 12 | 1406.6 | 1 | UniProt (Q15596) In PDB | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
3 | A | MOMETASONE FUROATE | non-polymer | 521.4 | 1 | Chemie (MOF) | |||
4 | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 526 - 777 (UniProt: P04150)
B: 741 - 752 (UniProt: Q15596)
PDB | External Database | Details |
---|---|---|
Ala 602 | Phe 602 | engineered mutation |
Tyr 622 | Cys 622 | engineered mutation |
Val 668 | Thr 668 | engineered mutation |
Thr 674 | Ser 674 | engineered mutation |
Ile 675 | Val 675 | engineered mutation |
Ala 699 | Lys 699 | engineered mutation |
Ala 703 | Lys 703 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 741 | Glu 741 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 30690.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 521.4 | |
All* | Total formula weight | 31212.1 |