4NCO
Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I | BG505 SOSIP gp120 | polymer | 475 | 53121.1 | 3 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
| 2 | B, F, J | BG505 SOSIP gp41 | polymer | 78 | 6656.2 | 3 | Human immunodeficiency virus 1 | ||
| 3 | C, G, K | PGT122 light chain | polymer | 211 | 22712.1 | 3 | Homo sapiens (human) | ||
| 4 | D, H, L | PGT122 heavy chain | polymer | 235 | 25434.7 | 3 | Homo sapiens (human) | ||
| 5 | a, b, M, N, O... | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 12 | In PDB GlyTouCan (G55220VL) | |||
| 6 | c, Q, W | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 3 | In PDB GlyTouCan (G04216GB) | |||
| 7 | d, R, X | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose | branched | 342.3 | 3 | In PDB BIRD (PRD_900111) GlyTouCan (G53402KW) | 2alpha-alpha-mannobiose | ||
| 8 | I, A, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 30 | Chemie (NAG) |
Sequence modifications
A, E, I: 31 - 507 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Asn 332 | Thr 330 | engineered mutation |
| Cys 501 | Ala 498 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 323772.2 | |
| Branched | Number of molecules | 18 |
| Total formula weight | 20526.3 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 6636.2 | |
| All* | Total formula weight | 350934.8 |
