4AW2

Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	SERINE/THREONINE-PROTEIN KINASE MRCK ALPHA	polymer	437	50271.9	1	UniProt (O54874) Pfam (PF00069) Pfam (PF00433) In PDB	RATTUS NORVEGICUS (NORWAY RAT)	CDC42-BINDING PROTEIN KINASE ALPHA, MYOTONIC DYSTROPHY KINASE-RELATED CDC42-BINDING KINASE ALPHA, MRCK ALPHA, MYOTONIC DYSTROPHY PROTEIN KINASE-LIKE ALPHA CDC42 BINDING PROTEIN KINASE ALPHA
2	A	5,11-dimethyl-1-oxo-2,6-dihydro-1h-pyrido[4,3-b]carbazol-9-yl benzoate	non-polymer		382.4	1	Chemie (22E)
3	A	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
4		water	water		18.0	211	Chemie (HOH)

Sequence modifications

A: 2 - 424 (UniProt: O54874)

PDB	External Database	Details
Ala 425	-	expression tag
Glu 426	-	expression tag
Asn 427	-	expression tag
Leu 428	-	expression tag
Tyr 429	-	expression tag
Phe 430	-	expression tag
Gln 431	-	expression tag
Ser 432	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
Gly 254	Asp 254	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	50271.9
Non-Polymers*	Number of molecules	5
	Total formula weight	630.7
All*	Total formula weight	50902.6

*Water molecules are not included.