4AW2

Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 22E A 500

Chain	Residue
A	ASP33
A	LYS339
A	HOH2099
A	HOH2210
A	ILE36
A	LYS68
A	GLN69
A	ARG71
A	HIS73
A	GLN145
A	ASP146
A	ASP147

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1418

Chain	Residue
A	TYR56
A	TRP59
A	ARG123
A	LEU397
A	PRO398
A	HOH2202

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1419

Chain	Residue
A	LYS106
A	LEU108
A	ALA120
A	CYS121
A	GLU125
A	GLY221
A	HOH2063

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1420

Chain	Residue
A	ALA104
A	TYR156
A	TYR157
A	HOH2105

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1421

Chain	Residue
A	GLU29
A	ARG71
A	CYS408
A	LEU410
A	HOH2206

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGAFGEVAvVklknadkv..........FAMK

Chain	Residue	Details
A	ILE83-LYS106

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. YvHrDIKpdNILM

Chain	Residue	Details
A	TYR197-MET209

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P54265, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP201

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P54265, ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE83

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:9418861

Chain	Residue	Details
A	LYS106

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:Q5VT25

Chain	Residue	Details
A	SER222
A	SER234

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000250|UniProtKB:Q5VT25

Chain	Residue	Details
A	THR240

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