4AQE

CRYSTAL STRUCTURE OF DEAFNESS ASSOCIATED MUTANT MOUSE CADHERIN-23 EC1- 2S70P AND PROTOCADHERIN-15 EC1-2 FORM I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	CADHERIN-23	polymer	214	23866.5	1	UniProt (Q99PF4) Pfam (PF00028) In PDB	MUS MUSCULUS (HOUSE MOUSE)	OTOCADHERIN
2	B	PROTOCADHERIN-15	polymer	242	27502.6	1	UniProt (Q99PJ1) Pfam (PF18432) Pfam (PF00028) In PDB	MUS MUSCULUS (HOUSE MOUSE)
3	A, B	CALCIUM ION	non-polymer		40.1	7	Chemie (CA)
4	A	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
5	B	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
6		water	water		18.0	403	Chemie (HOH)

Sequence modifications

A: 2 - 206 (UniProt: Q99PF4)

PDB	External Database	Details
Met 1	-	expression tag
Leu 207	-	expression tag
Glu 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag
Pro 48	Ser 70	engineered mutation

B: 1 - 233 (UniProt: Q99PJ1)

PDB	External Database	Details
Met 0	-	expression tag
Leu 234	-	expression tag
Glu 235	-	expression tag
His 236	-	expression tag
His 237	-	expression tag
His 238	-	expression tag
His 239	-	expression tag
His 240	-	expression tag
His 241	-	expression tag
Tyr 8	Phe 34	SEE REMARK 999
Asp 10	Asn 36	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51369.1
Non-Polymers*	Number of molecules	9
	Total formula weight	514.9
All*	Total formula weight	51884.0

*Water molecules are not included.