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4AQ3

HUMAN BCL-2 WITH PHENYLACYLSULFONAMIDE INHIBITOR

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D, E...APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1polymer16919509.76UniProt (P10415)
UniProt (Q07817)
Pfam (PF02180)
Pfam (PF00452)
In PDB
HOMO SAPIENS (HUMAN)BCL2-L-1, APOPTOSIS REGULATOR BCL-X
2A, B, C, D, E...N,N-dibutyl-4-chloranyl-1-[2-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-4-[(7-iodanylnaphthalen-2-yl)sulfonylcarbamoyl]phenyl]-5-methyl-pyrazole-3-carboxamidenon-polymer866.26Chemie (398)
Sequence modifications
A, B, C, D, E, F: 1 - 33 (UniProt: P10415)
PDBExternal DatabaseDetails
Gly -2-expression tag
Ser -1-expression tag
His 0-expression tag
A, B, C, D, E, F: 51 - 166 (UniProt: P10415)
PDBExternal DatabaseDetails
Asp 34-expression tag
Ala 55Thr 96variant
Gly 69Arg 110variant
A, B, C, D, E, F: 35 - 50 (UniProt: Q07817)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight117058.0
Non-Polymers*Number of molecules6
Total formula weight5197.2
All*Total formula weight122255.2
*Water molecules are not included.

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PDB entries from 2024-04-24

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