3U85

Crystal structure of human menin in complex with MLL1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Menin	polymer	550	61061.2	1	UniProt (O00255) Pfam (PF05053) In PDB	Homo sapiens (Human)
2	B	Histone-lysine N-methyltransferase 2A	polymer	21	2148.4	1	UniProt (Q03164) In PDB	Homo sapiens (Human)	Lysine N-methyltransferase 2A,ALL-1,CXXC-type zinc finger protein 7,Myeloid/lymphoid or mixed-lineage leukemia,Myeloid/lymphoid or mixed-lineage leukemia protein 1,Trithorax-like protein,Zinc finger protein HRX

Sequence modifications

A: 2 - 459 (UniProt: O00255)

PDB	External Database	Details
Ser 1	-	expression tag

A: 520 - 610 (UniProt: O00255)
B: 6 - 25 (UniProt: Q03164)

PDB	External Database	Details
Ser 5	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	63209.6
All*	Total formula weight	63209.6

*Water molecules are not included.