3SOC
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Activin receptor type-2A | polymer | 322 | 36548.8 | 2 | UniProt (P27037) Pfam (PF00069) In PDB | Homo sapiens (human) | Activin receptor type IIA, ACTR-IIA, ACTRIIA |
2 | A, B | [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE | non-polymer | 381.4 | 2 | Chemie (GVD) | |||
3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
4 | water | water | 18.0 | 540 | Chemie (HOH) |
Sequence modifications
A, B: 191 - 488 (UniProt: P27037)
PDB | External Database | Details |
---|---|---|
Met -23 | - | expression tag |
Gly -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
Ser -15 | - | expression tag |
Ser -14 | - | expression tag |
Gly -13 | - | expression tag |
Val -12 | - | expression tag |
Asp -11 | - | expression tag |
Leu -10 | - | expression tag |
Gly -9 | - | expression tag |
Thr -8 | - | expression tag |
Glu -7 | - | expression tag |
Asn -6 | - | expression tag |
Leu -5 | - | expression tag |
Tyr -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Ser -1 | - | expression tag |
Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 73097.5 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 1445.6 | |
All* | Total formula weight | 74543.1 |