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3SOC

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin

Summary for 3SOC
Entry DOI10.2210/pdb3soc/pdb
Related3Q4T
DescriptorActivin receptor type-2A, [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsstructural genomics consortium, sgc, transferase, protein kinase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P27037
Total number of polymer chains2
Total formula weight74543.15
Authors
Primary citationChaikuad, A.,Williams, E.,Mahajan, P.,Cooper, C.D.O.,Sanvitale, C.,Vollmar, M.,Muniz, J.R.C.,Yue, W.W.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC)
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin
To be Published,
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

PDB entries from 2024-03-27

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