3RVG
Crystals structure of Jak2 with a 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase JAK2 | polymer | 303 | 35795.8 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (human) | Janus kinase 2, JAK-2 |
2 | A | 1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide | non-polymer | 388.5 | 1 | Chemie (17P) | |||
3 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 835 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Met 834 | - | EXPRESSION TAG |
Leu 1133 | - | EXPRESSION TAG |
Val 1134 | - | EXPRESSION TAG |
Pro 1135 | - | EXPRESSION TAG |
Arg 1136 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35795.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 388.5 | |
All* | Total formula weight | 36184.3 |