Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3RVG

Crystals structure of Jak2 with a 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitor

Summary for 3RVG
Entry DOI10.2210/pdb3rvg/pdb
DescriptorTyrosine-protein kinase JAK2, 1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide (3 entities in total)
Functional Keywordstyrosine kinase, janus kinase 2, enzyme inhibitors, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationEndomembrane system ; Peripheral membrane protein : O60674
Total number of polymer chains1
Total formula weight36184.25
Authors
Primary citationLim, J.,Taoka, B.,Otte, R.D.,Spencer, K.,Dinsmore, C.J.,Altman, M.D.,Chan, G.,Rosenstein, C.,Sharma, S.,Su, H.P.,Szewczak, A.A.,Xu, L.,Yin, H.,Zugay-Murphy, J.,Marshall, C.G.,Young, J.R.
Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders.
J.Med.Chem., 54:7334-7349, 2011
Cited by
PubMed: 21942426
DOI: 10.1021/jm200909u
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.498 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon