3NS7
Succinic Acid Amides as P2-P3 Replacements for Inhibitors of Interleukin-1beta Converting Enzyme (ICE or Caspase 1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Caspase-1 | polymer | 162 | 18298.1 | 1 | UniProt (P29466) Pfam (PF00656) In PDB | Homo sapiens (human) | CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme, ICE, p45, Caspase-1 subunit p20, Caspase-1 subunit p10 |
| 2 | B | Caspase-1 | polymer | 88 | 10258.8 | 1 | UniProt (P29466) Pfam (PF00656) In PDB | Homo sapiens (human) | CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme, ICE, p45, Caspase-1 subunit p20, Caspase-1 subunit p10 |
| 3 | B | (3S)-4-hydroxy-3-{[(2S)-4-{[2-(2-methyl-1H-benzimidazol-1-yl)ethyl]amino}-2-(1-methylethyl)-4-oxobutanoyl]amino}butanoic acid | non-polymer | 418.5 | 1 | BIRD (PRD_001011) Chemie (3NS) | |||
| 4 | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28556.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 418.5 | |
| All* | Total formula weight | 28975.3 |
