3NS7

Succinic Acid Amides as P2-P3 Replacements for Inhibitors of Interleukin-1beta Converting Enzyme (ICE or Caspase 1)

Summary for 3NS7

Entry DOI	10.2210/pdb3ns7/pdb
Related PRD ID	PRD_001011
Descriptor	Caspase-1, (3S)-4-hydroxy-3-{[(2S)-4-{[2-(2-methyl-1H-benzimidazol-1-yl)ethyl]amino}-2-(1-methylethyl)-4-oxobutanoyl]amino}butanoic acid, ... (4 entities in total)
Functional Keywords	cysteine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P29466 P29466
Total number of polymer chains	2
Total formula weight	28975.34
Authors	Galatsis, P. (deposition date: 2010-07-01, release date: 2011-08-17, Last modification date: 2023-12-27)
Primary citation	Galatsis, P.,Caprathe, B.,Gilmore, J.,Thomas, A.,Linn, K.,Sheehan, S.,Harter, W.,Kostlan, C.,Lunney, E.,Stankovic, C.,Rubin, J.,Brady, K.,Allen, H.,Talanian, R. Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1). Bioorg.Med.Chem.Lett., 20:5184-5190, 2010 Cited by PubMed: 20656488 DOI: 10.1016/j.bmcl.2010.07.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation