3NIG
The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Integrin alpha-IIb | polymer | 457 | 49516.0 | 2 | UniProt (P08514) Pfam (PF01839) In PDB | Homo sapiens (human) | Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, Integrin alpha-IIb heavy chain |
2 | B, D | Integrin beta-3 | polymer | 471 | 51958.8 | 2 | UniProt (P05106) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) In PDB | Homo sapiens (human) | Platelet membrane glycoprotein IIIa, GPIIIa, CD61 |
3 | E, H | Monoclonal antibody 10E5 heavy chain | polymer | 221 | 23766.5 | 2 | Mus musculus (mouse) | ||
4 | F, L | Monoclonal antibody 10E5 light chain | polymer | 214 | 23332.7 | 2 | Mus musculus (mouse) | ||
5 | G, J | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G62182OO) | |||
6 | I, K | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
7 | C, D, A, B | CALCIUM ION | non-polymer | 40.1 | 12 | Chemie (CA) | |||
8 | C, A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
9 | C, D, L, A | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
10 | D, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
11 | D, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
12 | water | water | 18.0 | 1227 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 297147.8 | |
Branched | Number of molecules | 4 |
Total formula weight | 2021.9 | |
Non-Polymers* | Number of molecules | 25 |
Total formula weight | 1824.6 | |
All* | Total formula weight | 300994.3 |