3LU9
Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D | Prothrombin | polymer | 46 | 5367.9 | 2 | UniProt (P00734) Pfam (PF09396) In PDB | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
| 2 | B, E | Prothrombin | polymer | 259 | 29764.2 | 2 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
| 3 | C, F | Proteinase-activated receptor 1 | polymer | 25 | 2998.3 | 2 | UniProt (P25116) In PDB | Homo sapiens (human) | PAR-1, Thrombin receptor, Coagulation factor II receptor |
| 4 | B, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | B, E | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | water | water | 18.0 | 698 | Chemie (HOH) |
Sequence modifications
B, E: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 76260.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 580.5 | |
| All* | Total formula weight | 76841.3 |
