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3LU9

Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1

Summary for 3LU9
Entry DOI10.2210/pdb3lu9/pdb
Related1SHH
DescriptorProthrombin, Proteinase-activated receptor 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordsserine protease, acute phase, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, pharmaceutical, polymorphism, protease, secreted, zymogen, cell membrane, g-protein coupled receptor, membrane, phosphoprotein, receptor, transducer, transmembrane
Biological sourceHomo sapiens (human)
More
Total number of polymer chains6
Total formula weight76841.28
Authors
Gandhi, P.S.,Chen, Z.,Di Cera, E. (deposition date: 2010-02-17, release date: 2010-03-16, Last modification date: 2023-09-06)
Primary citationGandhi, P.S.,Chen, Z.,Di Cera, E.
Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1.
J.Biol.Chem., 285:15393-15398, 2010
Cited by
PubMed: 20236938
DOI: 10.1074/jbc.M110.115337
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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