3L2C

Crystal Structure of the DNA Binding Domain of FOXO4 Bound to DNA

Replaces:  3BPY

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	FOXO consensus binding sequence, plus strand	polymer	13	3943.6	1
2	C	FOXO consensus binding sequence, minus strand	polymer	13	3996.6	1
3	A	Forkhead box protein O4	polymer	110	12276.7	1	UniProt (P98177) Pfam (PF00250) In PDB	Homo sapiens (human)	Forkhead transcription factor FOXO4, Fork head domain transcription factor AFX1
4	C, A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5		water	water		18.0	163	Chemie (HOH)

Sequence modifications

A: 82 - 183 (UniProt: P98177)

PDB	External Database	Details
Gly 74	-	expression tag
Ser 75	-	expression tag
His 76	-	expression tag
Met 77	-	expression tag
Leu 78	-	expression tag
Glu 79	-	expression tag
Asp 80	-	expression tag
Pro 81	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	20217.0
Non-Polymers*	Number of molecules	2
	Total formula weight	48.6
All*	Total formula weight	20265.6

*Water molecules are not included.