3K9F
Detailed structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | DNA topoisomerase 4 subunit A | polymer | 496 | 56455.4 | 2 | UniProt (P72525) Pfam (PF00521) In PDB | Streptococcus pneumoniae | Topoisomerase IV subunit A |
2 | C, D | DNA topoisomerase 4 subunit B | polymer | 268 | 30415.7 | 2 | UniProt (Q59961) Pfam (PF01751) Pfam (PF00986) In PDB | Streptococcus pneumoniae | Topoisomerase IV subunit B |
3 | E | DNA (5'-D(*AP*CP*CP*AP*AP*GP*GP*T*CP*AP*TP*GP*AP*AP*T)-3') | polymer | 15 | 4602.0 | 1 | |||
4 | F | DNA (5'-D(P*AP*GP*TP*CP*AP*TP*TP*CP*AP*TP*GP*AP*CP*CP*TP*TP*GP*GP*T)-3') | polymer | 19 | 5810.8 | 1 | |||
5 | G | DNA (5'-D(*CP*TP*GP*TP*TP*TP*TP*A*CP*GP*TP*GP*CP*AP*T)-3') | polymer | 15 | 4566.0 | 1 | |||
6 | H | DNA (5'-D(P*GP*AP*CP*TP*AP*TP*GP*CP*AP*CP*GP*TP*AP*AP*AP*AP*CP*AP*G)-3') | polymer | 19 | 5846.8 | 1 | |||
7 | C, D | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
8 | F, H | (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid | non-polymer | 361.4 | 2 | Chemie (LFX) | |||
9 | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 488 (UniProt: P72525)
C, D: 404 - 647 (UniProt: Q59961)
PDB | External Database | Details |
---|---|---|
Leu 489 | - | expression tag |
Glu 490 | - | expression tag |
His 491 | - | expression tag |
His 492 | - | expression tag |
His 493 | - | expression tag |
His 494 | - | expression tag |
His 495 | - | expression tag |
His 496 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 380 | - | initiating methionine |
Gly 381 | - | expression tag |
His 382 | - | expression tag |
His 383 | - | expression tag |
His 384 | - | expression tag |
His 385 | - | expression tag |
His 386 | - | expression tag |
His 387 | - | expression tag |
His 388 | - | expression tag |
His 389 | - | expression tag |
His 390 | - | expression tag |
His 391 | - | expression tag |
Ser 392 | - | expression tag |
Ser 393 | - | expression tag |
Gly 394 | - | expression tag |
His 395 | - | expression tag |
Ile 396 | - | expression tag |
Asp 397 | - | expression tag |
Asp 398 | - | expression tag |
Asp 399 | - | expression tag |
Asp 400 | - | expression tag |
Lys 401 | - | expression tag |
His 402 | - | expression tag |
Met 403 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 194567.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 771.3 | |
All* | Total formula weight | 195339.2 |