3IPS
X-ray structure of benzisoxazole synthetic agonist bound to the LXR-alpha
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Oxysterols receptor LXR-alpha | polymer | 283 | 32866.4 | 2 | UniProt (Q13133) Pfam (PF00104) In PDB | Homo sapiens (human) | Liver X receptor alpha, Nuclear orphan receptor LXR-alpha, Nuclear receptor subfamily 1 group H member 3 |
2 | C, D | Nuclear receptor coactivator 1 | polymer | 25 | 2806.2 | 2 | UniProt (Q15788) Pfam (PF08832) In PDB | NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52 | |
3 | A, D | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | A, B | {3-chloro-4-[(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)sulfanyl]phenyl}acetic acid | non-polymer | 487.9 | 2 | Chemie (O90) | |||
5 | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A, B: 182 - 447 (UniProt: Q13133)
PDB | External Database | Details |
---|---|---|
Met 165 | - | expression tag |
Lys 166 | - | expression tag |
His 167 | - | expression tag |
Gln 168 | - | expression tag |
His 169 | - | expression tag |
Gln 170 | - | expression tag |
His 171 | - | expression tag |
Gln 172 | - | expression tag |
His 173 | - | expression tag |
Gln 174 | - | expression tag |
His 175 | - | expression tag |
Gln 176 | - | expression tag |
His 177 | - | expression tag |
Gln 178 | - | expression tag |
Gln 179 | - | expression tag |
Pro 180 | - | expression tag |
Leu 181 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 71345.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1168.0 | |
All* | Total formula weight | 72513.1 |