3IPS

X-ray structure of benzisoxazole synthetic agonist bound to the LXR-alpha

Summary for 3IPS

Entry DOI	10.2210/pdb3ips/pdb
Related	3IPQ 3IPU
Descriptor	Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, SULFATE ION, ... (5 entities in total)
Functional Keywords	nuclear receptor, lxr homodimer, lxr signaling, alternative splicing, nucleus, polymorphism, receptor, transcription, transcription regulation, activator, isopeptide bond, proto-oncogene, cholesterol, abca1, heterodimer, rxr, ligand complex
Biological source	Homo sapiens (human) More
Cellular location	Nucleus (Potential): Q13133 Nucleus (By similarity): Q15788
Total number of polymer chains	4
Total formula weight	72513.07
Authors	Fradera, X.,Vu, D.,Nimz, O.,Skene, R.,Hosfield, D.,Wijnands, R.,Cooke, A.J.,Haunso, A.,King, A.,Bennet, D.J.,McGuire, R.,Uitdehaag, J.C.M. (deposition date: 2009-08-18, release date: 2010-06-02, Last modification date: 2024-04-03)
Primary citation	Fradera, X.,Vu, D.,Nimz, O.,Skene, R.,Hosfield, D.,Wynands, R.,Cooke, A.J.,Haunso, A.,King, A.,Bennett, D.J.,McGuire, R.,Uitdehaag, J.C. X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling. J.Mol.Biol., 399:120-132, 2010 Cited by PubMed: 20382159 DOI: 10.1016/j.jmb.2010.04.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation